Beilstein J. Org. Chem.2020,16, 1234–1276, doi:10.3762/bjoc.16.107
-oxyl radicals, oxime radicals (or iminoxylradicals) have been underestimated for a long time as useful intermediates for organic synthesis, despite the fact that their precursors, oximes, are extremely widespread and easily available organic compounds. Furthermore, oxime radicals are structurally
the last decade, when numerous selective reactions of oxidative cyclization, functionalization, and coupling mediated by iminoxylradicals were discovered. This review is focused on the synthetic methods based on iminoxylradicals developed in the last ten years and also contains some selected data on
reactions of oxime radicals. These reactions are classified into cyclizations involving C–H bond cleavage and cyclizations involving a double C=C bond cleavage.
Keywords: iminoxylradicals; isoxazolines; oxidative cyclization; oxime radicals; oximes; Introduction
Free radicals in which an unpaired
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Graphical Abstract
Figure 1:
Imine-N-oxyl radicals (IV) discussed in the present review and other classes of N-oxyl radicals (I–...